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Table 1 Summary of treatment and outcome

From: Benign juvenile idiopathic epilepsy in captive Iberian lynx (Lynx pardinus) in the ex situ conservation program (2005–2019)

Case Sex ASO ATO ALRS AET Treatment Outcome
1 M 75 78 104 896 PHB Epilepsy remission. Died at 3920 days. Postmortem: CRD
2 M 71 73 107 610 PHB Epilepsy remission. Phenobarbital dose 0.44 mg/kg/SID since day 373. Died at 631 days. Postmortem: CRD.
3 M 116 124 125 712 PHB Epilepsy remission. Died at 1409 days. Postmortem: CRD
4 M 157 – – 191 – Died at 192 days. Postmortem: Bacterial septicaemia (Salmonella spp)
5 M 75 77 457 Unfinished PHB ES remission. Phenobarbital dose 0.6 mg/kg/SID since day 1537. Current age 3543 days
6 M 63 64 76 Unfinished PHB Died at 134 days. Postmortem: Oesophageal foreign body.
7 F 69 82 1599 Unfinished PHB, IMP Died at 2526 days. Postmortem: Cardiac insufficiency.
8 F 62 66 87 452 PHB Epilepsy remission. Current age 2845 days.
9 F 77 78 77 482 PHB Epilepsy remission. Current age 2835 days.
10 F 64 66 398 Unfinished PHB Died at 428 days during cluster ES. Postmortem: Multiorgan failure and DIC associated with haemorrage and oedema affecting piriform and temporal lobes bilaterally.
11 F 64 65 66 99 PHB Epilepsy remission. Current age 2101 days.
12 M 795 796 857 Unfinished PHB, IMP ES remission. Current age 2104 days.
13 M 74 75 140 Unfinished PHB ES remission. Phenobarbital dose 0.46 mg/kg/SID since day 522. Current age 1738 days.
14 M 67 68 68 1648 PHB Epilepsy remission. Phenobarbital dose 0.42 mg/kg/SID since day 522. Current age 1738 days.
15 F 63 72 827 Unfinished PHB, IMP Euthanasia performed at 853 days due to a severe deterioration and poor quality of live. Postmortem: no significant findings.
16 F 65 71 900 Unfinished PHB, IMP ES remission. Current age 1753 days.
17 M 66 70 317 Unfinished PHB ES remission. Current age 1398 days.
18 M 63 67 451 Unfinished PHB, IMP Died at 451 days. Postmortem: Bacterial septicaemia (Streptococcus spp)
19 M 60 80 79 361 PHB, IMP Epilepsy remission. Imepitoin started due to an early withdrawal of phenobarbital. Current age 956 days.
20 F 73 75 1148 Unfinished PHB, LVT, PGB, ZNS Euthanasia performed at 1157 days due to a severe deterioration and poor quality of live. Postmortem: no significant findings.
  1. Ages in days. ASO age at seizure onset, ATO age at treatment onset (phenobarbital), ALRS Age at last reported seizure, AET age at the end of treatment, PHB Phenobarbital, IMP imepitoin, LVT levetiracetam, PGB pregabalin, ZNS zonisamide, CRD chronic renal disease, ES Epileptic Seizure, DIC Disseminated intravascular coagulation
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BMC Veterinary Research

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