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Table 1 Heterozygous polymorphism in exonic sequence of TERT gene in four different dog breeds

From: Polymorphisms within the Telomerase Reverse Transcriptase gene (TERT) in four breeds of dogs selected for difference in lifespan and cancer susceptibility

Exon Nucleotide BP change Codon change Individuals
3 4395 A to M (A or C) Thr to Pro¶ DS 1; NF 4; IW 2 & 3
3 4428 T to Y (C or T) Cys to Arg¶ DS 1 & 3; NF 1, 3, & 5; IW 4
3 4478 T to W (A or T) Phe to Tyr¶ DS 1; NF 3, 4 & 5
3 4517 A to M (A or C) Ser to Ser DS 1; NF 3; ST 1
3 4526 A to R (A or G) Gly to Gly DS 2; NF 1 & 2
3 4547 C to Y (C or T) Tyr to Tyr DS 1, 2 & 4; NF 1, 2, 3, 4, & 5; ST 3 & 5; IW 1
3 4548 A to M (A or C) Arg to Arg DS 4; IW 5; ST 1, 4, & 5
4 5454 A to M (A or C) Gln to Pro¶ DS 1; NF 1 & 5; ST 1
4 5467 T to Y (C or T) Pro to Pro DS 1, 3, 4, & 5; NF 4 & 5; ST 2; IW 1
4 5511 A to M (A or C) Gln to Pro¶ DS 1, 3, 4, & 5; NF 3 & 5; ST 2; IW 1
6 7125 T to Y (C or T) Leu to Pro¶ DS 1 & 2; IW 2 & 4
12 14458 G to S (G or C) Pro to Pro DS 2 & 3; NF 5
17 18322 C to S (G or C) His to Asp¶ DS 5; ST 4; IW 1, 4, &5
17 18329 G to R (A or G) Stop to Stop DS 5; ST 4; IW 2
  1. ¶ = Potentially deleterious mutation.
  2. DS = Dachsund.
  3. NF = Newfoundland.
  4. ST = Shi Tzu.
  5. IW = Irish Wolfhound.
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BMC Veterinary Research

ISSN: 1746-6148

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